KNEE PAIN?

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BIO-CHIP

BIOengineered grafts for Cartilage Healing in Patients

01

The Problem

The Problem
Cartilage tissue has a limited capacity for self-repair. Articular cartilage injuries that are not properly treated cause pain and disability, and double the incidence of degenerative joint problems in the elderly. Cartilage repair treatments do have the potential to relieve pain and improve the quality...
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02

The Project

The Project
In an effort to overcome the limitations of currently available treatments, the BIO-CHIP project aims at carrying out a phase II clinical trial (Nose To Knee II) for the treatment of traumatic cartilage lesions in the knee, with two main innovations: the use of autologous nasal chondrocytes as a cell so...
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03

The Science

The Science
Established cell based therapies for cartilage repair still have major drawbacks and the only currently available ATMPs on the market have not demonstrated superiority of clinical efficacy Cartilage tissues engineered from nasal chondrocytes display features of hyaline cartilage due to redifferentiated ..
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The Science

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  • Established cell based therapies for cartilage repair still have major drawbacks and the only currently available ATMPs on the market have not demonstrated superiority of clinical efficacy

  • Cartilage tissues engineered from nasal chondrocytes display features of hyaline cartilage due to redifferentiated chondrocytes embedded in their own extracellular matrix and higher mechanical properties than cell-seeded scaffolds

  • Due to their higher proliferation rate and more reproducible chondrogenic capacity as well as the easy harvesting associated with minimal donor-site-morbidity, nasal chondrocytes represent a better cell source for cartilage graft engineering than articular chondrocytes

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 681103, BIO-CHIP.