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BIOengineered grafts for Cartilage Healing in Patients
Established cell based therapies for cartilage repair still have major drawbacks and the only currently available ATMPs on the market have not demonstrated superiority of clinical efficacy
Cartilage tissues engineered from nasal chondrocytes display features of hyaline cartilage due to redifferentiated chondrocytes embedded in their own extracellular matrix and higher mechanical properties than cell-seeded scaffolds
Due to their higher proliferation rate and more reproducible chondrogenic capacity as well as the easy harvesting associated with minimal donor-site-morbidity, nasal chondrocytes represent a better cell source for cartilage graft engineering than articular chondrocytes